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Glossary
Gout

You wake up in the middle of the night, and your big toe feels as if it's on fire. It's hot, swollen and so tender that even the weight of a blanket on it seems intolerable. These problems could indicate an acute attack of gout — or gouty arthritis — a form of arthritis that's characterized by sudden, severe attacks of pain, redness and tenderness in joints.
Gout is a complex disorder that can affect anyone. Men are more likely to get gout than women are, but women become increasingly susceptible to gout after menopause.
Gout is treatable, and there are ways to keep gout from recurring.

Signs and Symptoms of a Gout Attack:
A gout attack usually appears suddenly and may include:

  • Joint pain: Gout usually affects the large joint of your big toe which may feel hot, swollen and so tender that even the weight of a blanket on it seems intolerable.  but can occur in other locations such as your feet, ankles, knees, hands and wrists. The pain typically lasts five to 10 days and then stops. The discomfort subsides gradually over one to two weeks, leaving the joint apparently normal and pain-free.
  • Inflammation and redness. The affected joint or joints become swollen, tender and red.

Causes
The cause of gout is an inflammation in your joint resulting from an accumulation of urate crystals. Uric acid is a waste product formed from the breakdown of purines. These are substances found naturally in your body as well as in certain foods, especially organ meats — such as liver, brains, kidney and sweetbreads — and anchovies, herring, asparagus and mushrooms.
Normally, uric acid dissolves in your blood and passes through your kidneys into your urine. But sometimes your body either produces too much or excretes too little of this acid. In that case, uric acid can build up, forming sharp, needle-like crystals, uric acid, in a joint or surrounding tissue that cause pain, inflammation and swelling.

 

 

 


 

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Risk factors
The following conditions or circumstances can increase the chances you'll develop high levels of uric acid that may lead to gout:

  • Lifestyle factors. Excess consumption of alcohol is a common lifestyle factor that increases the risk of gout. Excess alcohol generally means more than two drinks a day for men and more than one for women.
  • Medical conditions. Certain diseases make it more likely that you'll develop gout. These include untreated high blood pressure, and chronic conditions, such as diabetes, high levels of fat and cholesterol in the blood and narrowing of the arteries.
  • Various medications. The use of diuretics which are  used to treat hypertension, and low-dose aspirin also can increase uric acid levels.
  • Genetics. About one out of five people with gout has a family history of the condition.
  • Age vs. Sex. Usually Gout occurs more often in men than it does in women, primarily because women tend to have lower uric acid levels than men do. Men also are more likely to develop gout earlier — usually between the ages of 40 and 50 — whereas women generally develop symptoms after menopause.

Treatment for Gout
The most common treatments for an acute attack of gout are high doses of nonsteroidal anti-inflammatory drugs (NSAIDs) taken orally (by mouth) or corticosteroids, which are taken orally or injected into the affected joint. NSAIDs reduce the inflammation caused by deposits of uric acid crystals but have no effect on the amount of uric acid in the body. The NSAIDs most commonly prescribed for gout are indomethacin (Indocin*) and naproxen (Anaprox, Naprosyn), which are taken orally every day.

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